2,000 MCQs | Clinical Scenarios | Questions, Options, Answers and Detailed Rationales

NursingManthra’s MRCGP Examination Review Material is designed for doctors preparing for the Applied Knowledge Test (AKT) component of the UK Membership of the Royal College of General Practitioners examination.

This question bank brings together 2,000 multiple-choice questions covering clinical medicine, evidence-based practice, data interpretation, and the professional and organisational responsibilities of UK general practice.

The material emphasises applying knowledge to realistic primary care situations. Questions explore diagnostic uncertainty, appropriate investigations, treatment selection, prescribing safety, urgent referral, preventive care, and the continuing management of patients with complex health needs.

What Does the Material Include?

Each MCQ follows a consistent learning format:

• Question: A clinical scenario, data interpretation task, or professional practice problem.
• Options: Multiple answer choices with one best answer.
• Answer: The correct option clearly identified.
• Rationale: An explanation of the correct answer and, where relevant, why alternative options are less appropriate.

Main Subjects Covered

Clinical Medicine and Patient Care

• Cardiovascular medicine and cardiovascular risk assessment
• Respiratory medicine
• Gastroenterology and liver disease
• Diabetes, endocrinology, and metabolic disorders
• Renal medicine and urology
• Neurology
• Musculoskeletal medicine and rheumatology
• Dermatology
• Ear, nose, throat, oral health, and hearing problems
• Ophthalmology and visual problems
• Haematology and recognition of suspected cancer
• Infectious diseases, immunisation, and travel health
• Allergy and clinical immunology
• Genomic medicine and inherited conditions
• Mental health and substance misuse
• Gynaecology, breast health, and menopause
• Maternity, contraception, reproductive and sexual health
• Child and adolescent health
• Older adult care, frailty, and multimorbidity
• Learning disabilities, neurodevelopmental conditions, and neurodiversity
• Palliative and end-of-life care
• Urgent and unscheduled care, red flags, and emergency referral
• Clinical pharmacology, medication monitoring, and safe prescribing
• Prevention, screening, and health promotion

Evidence-Based Practice and Data Interpretation

• Research methods and study designs
• Critical appraisal of clinical research
• Bias, confounding, and study limitations
• Sensitivity, specificity, and predictive values
• Relative risk, absolute risk reduction, and number needed to treat
• Confidence intervals and statistical significance
• Interpretation of tables, graphs, and clinical evidence
• Applying research findings to individual patient decisions

Primary Care Organisation and Professional Practice

• NHS primary care organisation and multidisciplinary working
• Medical ethics, consent, capacity, and confidentiality
• Safeguarding children and adults
• Documentation, information governance, and data protection
• Certification, statutory responsibilities, and professional accountability
• Clinical governance, audit, and quality improvement
• Patient safety, significant events, and complaints
• Equality, diversity, health inequalities, and access to care
• Communication, shared decision-making, and continuity of care

Clinical Reasoning Focus

Scenarios challenge candidates to identify the most appropriate next step when several options appear reasonable. Topics include recognising serious disease within common presentations, selecting proportionate investigations, managing competing treatment priorities, reviewing polypharmacy, and providing clear follow-up and safety-netting advice.

Who Is This Material For?

This resource is intended for doctors preparing for the UK MRCGP AKT, GP registrars consolidating their knowledge, and medical practitioners revising the principles of UK primary care.

Study with purpose: practise clinical decisions, understand the reasoning, and identify areas requiring further revision.